|
Bone Diseases, Developmental
|
0.300 |
Biomarker
|
group |
CTD_human |
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms.
|
17698054 |
2007 |
|
Gastrointestinal Stromal Tumors
|
0.300 |
Biomarker
|
group |
CTD_human |
Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.
|
27793025 |
2016 |
|
Craniofacial Abnormalities
|
0.300 |
Biomarker
|
group |
CTD_human |
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms.
|
17698054 |
2007 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Here we show that human basal cell carcinomas (BCCs) are frequently ciliated, and we test the role of cilia in BCC by conditionally deleting Kif3a (encoding kinesin family member 3A) or Ift88 (encoding intraflagellar transport protein 88), genes required for ciliogenesis, in two Hh pathway-dependent mouse tumor models.
|
19701205 |
2009 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Longitudinal microcomputed tomography (μCT) imaging and histopathological analyses revealed an increased rate of cyst formation, increased proportion of cysts with proliferating cells, higher frequency of atypical cysts as well as the development of neoplasms in Vhl/Kif3a/Trp53 mutant kidneys compared to Kif3a/Trp53 or Vhl/Kif3a mutant kidneys.
|
27126173 |
2016 |
|
Congenital Abnormality
|
0.010 |
Biomarker
|
group |
BEFREE |
BrdU activity analyses were carried out to examine how the loss of Kif3a affected cell proliferation and led to palate and tongue malformations.
|
27259005 |
2017 |
|
Immune System Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The kinesin family number 3A (KIF3A) gene on the human chromosomal 5q31-33 region, which is known as a susceptibility locus for immune diseases including asthma, plays a crucial role in generation of cilia.
|
20922562 |
2011 |
|
Polycystic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Using the yeast two-hybrid assay, we found that PC2 interacts with the microtubule-dependent motor kinesin-2 subunit KIF3A, a protein involved in polycystic kidney disease.
|
16950792 |
2006 |
|
Disorder of small intestine
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Antibodies to A4-Fla2, Fla-X, ASCA, and NOD2 mutations were significantly associated with small bowel disease (P = 0.013, P = 0.01, P < 0.001, P = 0.04), whereas ASCA was correlated with fistulizing disease (P = 0.007), and small bowel surgery (P = 0.009).
|
19253375 |
2009 |
|
Cystic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The Kif3a knockout mouse is an established non-orthologous mouse model of cystic kidney disease.
|
27181777 |
2016 |
|
Allergic Reaction
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
KIF3a promotes proliferation and invasion via Wnt signaling in advanced prostate cancer.
|
24413182 |
2014 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Knockdown of KIF3A expression alone suppressed cell migration and invasion, and attenuated ERK1/2/β-catenin/MMP7 signalling that was reactivated by knocking down PLCD1 in vitro.
|
28423710 |
2017 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo.
|
31774623 |
2019 |
|
aspirin intolerance
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Our findings suggest that the KIF3A gene and/or its polymorphisms might have a susceptibility effect on AIA, providing a new step toward controlling aspirin intolerance in asthmatics.
|
20922562 |
2011 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We identified a significant correlation between KIF3A and clinical features, including clinical stage (*p=0.047), pathologic tumor status (*p=0.045), lymph node status (*p=0.041), and metastasis (*p=0.035).
|
31774623 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
|
26760767 |
2016 |
|
Renal cyst
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Kidney-specific inactivation of Kif3a in newborn mice resulted in the loss of primary cilia and produced kidney cysts primarily in the loops of Henle, whereas inactivation in adult mice did not lead to the rapid development of cysts despite a comparable loss of primary cilia.
|
18263895 |
2008 |
|
Cleft secondary palate
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The objective of this study was to explore the molecular basis for cleft secondary palate and arrested tongue development caused by the loss of the intraflagellar transport protein, Kif3a.
|
27259005 |
2017 |
|
Asthma
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
The KIF3A rs12186803 risk allele interacted with food sensitization to increase asthma risk in children with eczema (P = 0.02).
|
30830718 |
2019 |
|
Asthma
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
Asthma
|
0.440 |
Biomarker
|
disease |
CTD_human |
The association between KIF3A rs7737031 and asthma was validated in 3 independent populations, further substantiating the validity of our gene selection approach.
|
21912604 |
2011 |
|
Asthma
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
|
Asthma
|
0.440 |
Biomarker
|
disease |
BEFREE |
This work aimed to investigate the role of KIF3A in epithelium apoptosis and bronchial inflammation in asthma.
|
29156524 |
2018 |
|
Asthma
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
|
31036433 |
2019 |